New year, new beginnings.
Over the years, this newsletter has grown to a readership of more than 200,000 people. We appreciate the interest, feedback, and support around our reports, analyses, and insights.
Going forward, we want to use this newsletter in a more focused way — to better serve our readers with rich, relevant information. So this marks a new approach for us. We’re calling it The Ecosystem Edge.
As we all know, collaborative startup ecosystems are a source of real competitive advantage for everyone involved. Through this newsletter, we’ll share our perspective on the trends shaping the global innovation ecosystem, and how those trends should inform what local leaders are thinking about and acting on.
The AI-Native shift
That context is especially important right now because the shifts we’re seeing in AI-Native innovation are already reshaping how startup ecosystems grow, compete, and compound value.
We’re seeing this unfold in every country we work in. AI-Native ecosystems are growing on a different curve. From 2020-2025, AI-Native Startup Ecosystem Value grew 12X faster than the rest of tech, now worth $1 trillion globally.
AI-Native ecosystems are already worth $1 trillion

© Startup Genome 2026
What’s powering that surge is a structural shift in how startups are built. AI-Native startups’ products and business models are built on AI from day one, enabling scaling through intelligence-driven workflows.
That changes the operating logic of entrepreneurship and pushes the boundaries of what’s possible. On a macroeconomic level, AI-Native innovation has the potential to redefine regional competitiveness in a fundamental way.
Silicon Valley still dominates across the board, but interestingly, Beijing is the far more AI-intense ecosystem by means of early-stage funding. Beyond the global tech powerhouses, there’s an opportunity to compress the gap for smaller innovation ecosystems with strong capabilities in AI-Native innovation.
The new AI-Native map
To quantify trends beyond the activities of Large Language Model providers such as OpenAI, X, Anthropic and other model builders, we map the AI-Native economy into three broad categories:
Model Builders (M): building proprietary models and platforms
Model Users (B): business models leveraging third-party AI models
Infrastructure (I): enabling AI workflows without providing AI themselves
Funding globally has surged across all three — but in 2024, VC investment in Model Builders jumped far ahead. Capital is signaling that the models themselves are seen as the next mega-value companies, with winner-takes-all dynamics emerging. Model Users still matter, but VCs are pricing Model Builders as the core value layer.
Now the obvious question: does the 2024 data – and the extreme valuation of some companies – show that we are in a bubble? Maybe. But even if last year’s funding proves overheated, the technology shift doesn’t disappear.
AI-Native startup funding has soared over the past decade

© Startup Genome 2026
What sits underneath this shift is speed. AI-Native startups are getting funded in less than half the time of other tech. In Beijing, an aggressive state strategy and deep pools of capital are compressing the path to seed to seven months on average. That pace is new, exciting — and should be concerning for everyone else.
AI-Native startups reach seed stage a year earlier across top hubs

© Startup Genome 2026
If Beijing can move that fast with state-backed velocity, the question for the rest of the world is clear: how do we make early-stage capital move at AI speed without state-scale funding? We’re already seeing clients experiment with levers like Fund-of-Funds injections to pull experienced VCs earlier into the market, and reforms aimed at cutting decision cycles. But the bigger bottleneck is still behavioral and institutional: rapid decision-making, and early-stage funders who actually know how to value AI companies.
So here’s the open question ecosystems need to answer: what does it take for angels and seed VCs to be twice as fast? How much of the drag is investor learning curve (which one could potentially compress with training and experienced hires) — and how much is bureaucracy that governments can slim down?
Are you staying ahead in the AI-Native era?
For policymakers and ecosystem leaders, this isn’t a passive trend to watch. It’s an active race to run because the rules of innovation are changing in real time. The question isn’t whether AI-Native will reshape your startup economy. It’s whether your ecosystem is set up to stay ahead of that curve.
Questions you need to answer now:
How do you protect and grow your startup economy in this new era?
Are your policies and programs actually keeping pace with AI-Native dynamics?
Are investors in your ecosystem fast and confident enough to fund AI-Native companies?
If you can’t answer these clearly, the risk is simple: AI-Native value will compound somewhere else.
Our Ecosystem Membership helps governments capture the economic value AI unlocks, with benchmarking and ecosystem intelligence, policy insights, and global positioning.
If you’re interested in designing strategies and policies to win in the AI era, reach out to Marina Krizman, our Head of Business Development.
How Startup Genome members are building an AI advantage

New York City is growing its AI momentum. NYCEDC’s “New York City’s AI Advantage” outlines 18 commitments to establish NYC as a global hub for Applied AI, including a $3M investment connecting startups with businesses, an AI advisory council, and a Startup Internship Program placing students in AI startups. The city is using platforms like NY Tech Week to amplify AI activity, and OpenAI’s 90,000-sq-ft NYC office underscores its rise as an AI hub.
Tel Aviv is an AI heavyweight. OpenAI co-founder Ilya Sutskever established a research lab in Tel Aviv to reach top talent for safe superintelligent AI company SSI. Meta launched AI Accelerator TLV, aimed at developing early-stage Israeli AI startups, and Nvidia acquired AI infrastructure startup Run:ai for $800M. The momentum continued with AI Week 2025 in December, showcasing the forefront of AI research and the application of intelligent systems.

Tokyo is growing its AI-Native edge. In 2024, Sakana AI became a unicorn just over a year after its founding. Singapore-based asset manager Seraya Partners launched AQX, a Tokyo-based digital infrastructure investment platform targeting shared telecom and AI-enabling infrastructure. Microsoft opened Microsoft Research Asia Tokyo, its first R&D center in Japan, to integrate AI with robotics.

Aligning with Abu Dhabi’s vision of becoming a leading technology hub, Hub71, Abu Dhabi’s global tech ecosystem, launched Hub71+ AI to support AI startups. Backed by partners like AWS and Google for Startups, it advances AI across key sectors to drive economic transformation. AI Abu Dhabi Forum took place in December, highlighting AI's real-world applications across financial systems.
